Sydney, Oct 30
Australian researchers have identified a previously unknown gene that influences the immune defence among indigenous people across Oceania, according to research published on Wednesday.
The research, which was published by The Peter Doherty Institute for Infection and Immunity in Melbourne, was the first of its kind to comprehensively map natural killer cells in Oceania's indigenous populations, news agency reported.
Natural killer cells are a type of white blood cell that play a crucial role in the body's first line of immune defence by destroying infected and diseased cells, restricting viruses from replicating in the earliest stages of infection.
The new research found that the highly variable natural killer cell receptor KIR3DL1 in Oceania's indigenous populations binds more tightly to human leukocyte antigens (HLA) molecules than KIR3DL1 forms that are predominant in other parts of the world.
Researchers said that the tighter binding changes the capacity of natural killer cells to sense and respond to infections.
They said the discovery could explain why indigenous people in Oceania, including Australasia, Melanesia, Micronesia, and Polynesia, are disproportionately affected by severe respiratory viral diseases, such as influenza and Covid-19, and could lead to improved prevention strategies.